What is it about?
Novel N-substituted indole derivatives were synthesized and evaluated against bacteria and fungi in vitro. The new compound, 1-(phenyl (piperidine-1-yl) methyl)-1H-indole, showed strong antibacterial and antifungal effects on Candida albicans, comparable to fluconazole, highlighting the importance of the indole motif in drug development.
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Why is it important?
Indoles are considered to play a significant role in drug discovery in almost all evaluations because of their extensive and varied biological actions. As a result, a lot of study has been done over the past few decades to synthesize and investigate the different medicinal possibilities of this moiety.
Perspectives
Novel N-substituted indole derivatives were synthesized and evaluated against bacteria and fungi in vitro. The compounds, including 1-(phenyl (piperidine-1-yl) methyl)-1H-indole and 4-(1H-indol-1-yl) (phenyl) morpholine, showed strong antifungal effects on Candida albicans, equivalent to fluconazole, highlighting the importance of the indole motif in drug development.
Professor Mamdouh Abdel-Monim Sofan
Faculty of Science-Damietta univ.
Read the Original
This page is a summary of: Antimicrobial Activity of N‐Substituted Derivatives of 5‐Chloro‐2,3‐ Diphenyl Indole, ChemistrySelect, December 2023, Wiley,
DOI: 10.1002/slct.202302922.
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