What is it about?
We describe a novel method for studying the central reaction underlying fibrinolysis, being plasminogen activation. This report presents the validation of our methodology and highlights the assay's favourable capabilities, including its simple and high-throughput capacity to effectively model the enzymatic characteristics of various plasminogen activators.
Featured Image
Photo by National Cancer Institute on Unsplash
Why is it important?
Although assays are available for measuring plasminogen activation, our unique method allows researchers to study plasminogen activation from the critical perspective of when plasminogen activators are applied to pre-existing clots. This is particularly relevant in the context of studying therapeutic applications of plasminogen activators (e.g. thrombolytic therapy), where treatment is only ever administered post-thrombogenesis.
Read the Original
This page is a summary of: A novel ex vivo approach for measuring plasminogen activation upon established plasma clots, Research and Practice in Thrombosis and Haemostasis, July 2022, Wiley,
DOI: 10.1002/rth2.12771.
You can read the full text:
Contributors
The following have contributed to this page
