What is it about?
This wok is about extracting more qualitative information from MALDI Q-TOF CID spectra of complex oligosaccharide mixtures, including isobaric precursor ion mixtures. The data analysis is based on product ion intensities, recognition of specific MS/MS patterns for various oligosaccharide structure types, and utilizing them for extraction of qualitative information. This study was performed on human milk oligosaccharides.
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Why is it important?
MS/MS analysis of glycomic data is very complex. Here we show that pattern recognition can significantly help analysis of complex MS/MS sepctra of oligosaccharides.
Perspectives
This method can be applied to obtain quantitative and semiquantitative from glycomic MS/MS data as well.
Dr Marko Haramija
University of Rijeka
Read the Original
This page is a summary of: Analysis of matrix-assisted laser desorption/ionization quadrupole time-of-flight collision-induced dissociation spectra of simple precursor ions and isobaric oligosaccharide ion mixtures based on product ion intensities and pattern recognition, Rapid Communications in Mass Spectrometry, April 2017, Wiley,
DOI: 10.1002/rcm.7855.
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