Preliminary mass spectrometry characterization studies of galectin-3 samples, prior to carbohydrate-binding studies using Affinity mass spectrometry

What is it about?

This work is about mass spectrometric characterization of real-life biological samples, for purposes of MS studies. It is relevant to protein purification, identification of protein modifications, as well as mass spectrometric characterization of a protein sample for further native nanoESI MS studies.

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Why is it important?

Functional MS studies using native ESI MS are complex due to their inherent property of analysis of ionized proteins in the gas phase. This area of research is in progress. However, protein sample purity and biophysical properties of the protein analyzed are equally important for native ESI MS studies, since MS is extremely sensitive, and MS data analysis requires detailed knowledge of qualitative and quantitative properties of a real-life sample.