What is it about?
Current evidence has shown antioxidant activity of artichoke as a potent source of antioxidant compounds. However, it seems that the antioxidant activity of artichoke has not yet been reviewed. Therefore, the present study was designed to perform a systematic review of human studies, animal models, and in vitro systems and to conduct a meta‐analysis of animal studies on the antioxidant effects of artichoke.
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Why is it important?
The results of in vitro systems supported the antioxidant effect of artichoke, whereas limited clinical trials indicated no change or a slight improvement of antioxidant status. Finding of animal studies indicated that artichoke extract supplementation increased superoxide dismutase, catalase, glutathione, and glutathione peroxidase level in liver, as well as, decreased malondialdehyde level in liver and plasma of animals with induced disease significantly compared with comparison group. This meta‐analysis provided convincing evidence for antioxidant activity of artichoke in animals.
Perspectives
More double‐blind placebo‐controlled randomized clinical trials are warranted to evaluate antioxidant activity of artichoke and to clarify effective dose, duration, and type (head or leaf) of artichoke and its extract in health or disease.
Khatereh Rezazadeh
Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Read the Original
This page is a summary of: The antioxidant activity of artichoke (Cynara scolymus
): A systematic review and meta-analysis of animal studies, Phytotherapy Research, October 2018, Wiley,
DOI: 10.1002/ptr.6213.
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