What is it about?
Artichoke leaf extract (ALE) has shown favorable effects on lipid profile and glucose level. Metabolic syndrome is a constellation of cardiometabolic abnormalities associated with increased risk of cardiovascular disease and Type 2 diabetes. Metabolic syndrome results from an interplay of environmental factors and genetic factors. Thus, we investigated the effects of ALE supplementation on metabolic parameters in women with metabolic syndrome, using a nutrigenetics approach.
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Why is it important?
We found for the first time that ALE supplementation may improve serum triglyceride level in A allele genotype of FTO‐rs9939609 polymorphism in women with metabolic syndome.
Perspectives
These findings highlight the need for further long‐term randomized clinical trials in a larger sample size to identify which group of patients with metabolic syndrome may particularly benefit from ALE supplementation.
Khatereh Rezazadeh
Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Read the Original
This page is a summary of: Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: Influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms, Phytotherapy Research, November 2017, Wiley,
DOI: 10.1002/ptr.5951.
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