What is it about?

Effect of Hypericum perforatum (St.-John's Wort) extract on the withdrawal syndrome of caffeine-addicted mice. Possible mechanism has also been evaluated by an appropriate experimental approach. Involvement of nitric oxide has been found out by using pharmacological antagonists.

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Why is it important?

Withdrawal symtoms may be troblesome for caffeine-addicted individuals. The findings obtained in the present study may have clinical relevance as St.-John's Wort is a commonly used OTC product.


More clinical studies are necessary for the future perspective.

Yusuf Ozturk

Read the Original

This page is a summary of: Extract of Hypericum perforatum blocks caffeine‐induced locomotor activity in mice: a possible role of nitric oxide, Phytotherapy Research, January 2007, Wiley,
DOI: 10.1002/ptr.2085.
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