What is it about?
We provide a validated integrative mathematical modelling pipeline that can be combined to predict clinical and epidemiological PrEP efficacy based on molecular parameters.
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Why is it important?
PK-PD studies for PrEP are unethical, leaving a knowledge gap when designing phase III studies. Our framework provides guidance by identifying pharmacological requirements for PrEP candidates and strategies and can be used to plan and evaluate clinical trials.
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This page is a summary of: Multiscale Systems-Pharmacology Pipeline to Assess the Prophylactic Efficacy of NRTIs Against HIV-1, CPT Pharmacometrics & Systems Pharmacology, July 2016, Wiley,
DOI: 10.1002/psp4.12095.
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