Synthesis of phosphonopeptides

What is it about?

Phosphonopeptides are potential inhibitors of enzymes and have been prepared convergently from amino amides (derived from naturally occurring amino acids), aldehydes, phosphorus trichloride through Mannich-type reaction followed by hydrolysis. The current synthetic method is a pseudo-four-component condensation reaction with easily available starting materials. It is also an ecconomic route.

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Why is it important?

The current synthetic method is convergent, ecconomic, and vesatile multiple component condensation.