What is it about?

This is the first study in which the pharmacokinetics and integrated dose measure of a mixture of bioactive chemicals in an herbal product is predicted by a model.

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Why is it important?

The integrated dose measure of bioactive chemicals helps to assess dose-response relation and safety assessment of an herbal product. The modeling approach described in this study is also applicable to the bioactive chemicals of other plant-based drugs, foods and nutraceuticals.

Perspectives

I hope PBPK modeling will be acceptable as a tool to provide useful information on the pharmacokinetics of bioactive chemicals in herbal medicines since model prediction needs confirmation by empirical studies in humans.

Francis Law
Simon Fraser University

Read the Original

This page is a summary of: Physiologically based pharmacokinetic modeling of tea catechin mixture in rats and humans, Pharmacology Research & Perspectives, April 2017, Wiley,
DOI: 10.1002/prp2.305.
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