What is it about?
3-Nitropropanoic acid (3NP) is a bioactive compound and proposed as an antitubercular agent, thus explaining by Macromolecular Crystallography.
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Why is it important?
The disease tuberculosis (TB) which is caused by the bacterium Mycobacterium Tuberculosis, is an infectious disease listed among the top 10 causes of fatality worldwide. It killed up to 1.4 million people in 2019 (WHO), thus making it as one of the top 10 causes of death.
Perspectives
We demonstrate 3-nitropropanoic acid (3NP) to be a micromolar inhibitor of InhA and report the crystal structure of the InhA-NAD+-3NP ternary complex, revealing the interactions between protein and inhibitor.
Dr. Chomphunuch Songsiriritthigul
Synchrotron Light Research Institute
Read the Original
This page is a summary of: Inhibition of
Mycobacterium tuberculosis
InhA
by 3‐nitropropanoic acid, Proteins Structure Function and Bioinformatics, October 2021, Wiley,
DOI: 10.1002/prot.26268.
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