Identifying membrane protein crystallization candidates with proteomics

What is it about?

Most drug targets are membrane proteins. However, membrane proteins are extremely difficult to crystallize, beyond the reach of most researchers. We demonstrate for the first time an experimental method to identify membrane proteins with physical properties that are more likely to crystallize.

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Why is it important?

We identify hundreds of membrane proteins from E. coli, yeast, and pig brain that are more likely to be crystallizable or well behaved biochemically. We hope this will facilitate the research of other membrane protein scientists.