What is it about?
Immune system plays a huge role in protecting host's body from potentially harmful substances including bacteria, virus, and also tumors. Many drugs have been found to also alter immune responses. We isolated membrane proteins from immune cells of lung cancer patients treated with chemotherapy. Our result provided novel insights on personalized immune profile and proposed a potential signatures to predict the response to treatment and prognosis.
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Why is it important?
Potentiating the immune system to fight the cancer cells has shown favorable improvement in survival. However, these immunotherapies still rely on combination with standard chemotherapy, and patient's response are diverse. We utilized robust protein analysis and show that chemotherapy alters immune response in terms of neutrophils, T cells, and antigen presentation pathways. We propose these immune profiles may provide information for immunotherapy combination.
Perspectives
The approach for personal-based medicine has gain huge attention and provide a way towards higher precision in treatment. I hope this article lights up the knowledge on drug-induced immune alteration, which impacts the overall progression of disease.
Denise Utami Putri
Taipei Medical University
Read the Original
This page is a summary of: Chemotherapy Immunophenoprofiles in Non-Small-Cell Lung Cancer by Personalized Membrane Proteomics, PROTEOMICS - CLINICAL APPLICATIONS, January 2018, Wiley,
DOI: 10.1002/prca.201700040.
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