What is it about?
A technique for online monitoring of the process of microparticle preparation using the solvent evaporation method is focused beam reflectance measurement (FBRM). FBRM is based on reflection measurement and strongly depends on the optical properties of particles. It does not require sampling that could affect the actual particle size distribution due to breakdown or aggregation. FBRM can be used to determine and monitor the chord length distribution (CLD), mean particle size and chord count of microparticles in real time, which are affected by the geometry, size and number of particles under analysis.
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Why is it important?
Focused beam reflectance measurement (FBRM) can be employed for online monitoring of the shift in the microparticle chord length distribution (CLD) and detect transformation of emulsion droplets into solid microparticles during the solvent evaporation process. The microparticle CLD and transformation process were strongly influenced by solvent type.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. This article also lead to polymer groups, microencapsulation groups, multiparticulate dosage forms groups contacting me and ultimately to a greater involvement in polymer, microencapsulation, and multiparticulate dosage forms research.
MUHAIMIN MUHAIMIN
University of Jambi, Indonesia
Read the Original
This page is a summary of: Effect of solvent type on preparation of ethyl cellulose microparticles by solvent evaporation method with double emulsion system using focused beam reflectance measurement, Polymer International, September 2017, Wiley,
DOI: 10.1002/pi.5436.
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