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Valproate, enteral clonidine, and phenobarbital are three agents with increasingly used for comfort in critically ill patients. This literature review describes the historical context, pharmacologic characteristics, supportive data, and practical considerations associated with the administration of these agents for comfort in critically ill adult patients.

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This page is a summary of: Repurposing Valproate, Enteral Clonidine, and Phenobarbital for Comfort in Adult ICU Patients: A Literature Review with Practical Considerations, Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy, October 2017, Wiley,
DOI: 10.1002/phar.2017.
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