What is it about?
Normal stem cells are widely accepted to be the cell of origin of most human cancers. However, there has been much debate as to where these cells are located in the normal human breast. Here, we use a technique that allows us to 'trace back' from a group of related cells to the stem cell and therefore permits us to identify their location.
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Why is it important?
This permits us to study the cell of origin of human breast cancer.
Perspectives
This technique may be able to help predict which patients are at risk of cancer by investigating the number and size of clonal expansions in the breast
Dr Stuart A McDonald
Queen Mary University of London
Read the Original
This page is a summary of: Analysis of clonal expansions through the normal and premalignant human breast epithelium reveals the presence of luminal stem cells, The Journal of Pathology, November 2017, Wiley,
DOI: 10.1002/path.4989.
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