What is it about?
MnCl2 shows potential as a MRI contrast agent that is directly sensitive to changes of intracellular Ca2+ homeostasis in early stage of intestinal I/R injury.
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Why is it important?
Accumulation of Mn2+ will cause a shorter T1 value, which in turn will increase signal intensity in T1-map MRI directly due to I/R.
Perspectives
Our investigation is the first to demonstrate that MEMRI at an low dose Mn2+ reveals the changes of Ca2+ homeostasis in small intestinal I/R injury associated with Ca2+ overload. It is an early, noninvasive, dynamic and in vivo medical imaging technique probably effectively providing clinical information for doctor to timely intervene protecting intestine from I/R injury.
Dr Yi Wang
Department of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing
Read the Original
This page is a summary of: Monitoring dynamic alterations in calcium homeostasis byT1-mapping manganese-enhanced MRI (MEMRI) in the early stage of small intestinal ischemia-reperfusion injury, NMR in Biomedicine, June 2015, Wiley,
DOI: 10.1002/nbm.3335.
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