What is it about?
Generally Ca2+ is needed to get fertilization in most aquatic animals. However, under voltage clamp at high negative voltage like -80 mV or in higher concentration of Ca2+ environment, sperm hardly enter the egg. We found it. and demonstrate that only Ca2+ can regulate sperm entry and the increase in Ca2+ at sperm site speeds up at higher clamped negative voltage such as -80 mV compared to at lower clamped voltage such as -20 mV.
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Why is it important?
Sperm entry is a quite important issue in study of fertilization mechanism. How is sperm entry regulated when sperm attaches to the egg and is entering the egg?
Perspectives
How Ca2+ regulates sperm entry is the next step of the study. Possibly there is an interplay between Ca2+ and cytoskeltal protein, actins. I would like to study the roles of actins and Ca2+.
pHD Tatsuma Mohri
National Institute for Physiological Sciences
Read the Original
This page is a summary of: Localized accumulation of cytosolic calcium near the fused sperm is associated with the calcium- and voltage-dependent block of sperm entry in the sea urchin egg, Molecular Reproduction and Development, August 2017, Wiley,
DOI: 10.1002/mrd.22866.
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