What is it about?
Chromosome separation need the assitance of tubulin organization. KIF1B plays role in transfer tubulin to the area where spindle formated. In female gamete, absence of KIF1B leads to abnormal spindle formation and subsequent chromosome separation failure, which will generate aneuploidy oocyte. Embryos fertilized by aneuploidy oocyte can not develop to term or gernerate babies with genetic disease.
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Why is it important?
Normal embryos come from the combination of healthy parental gametes. Abnormal oocytes such as those with incorrect number of chromosomes can not generate healthy embryos. If this kind of embryos implanted in uterus, early abortion or deliver of babyies with heathy problem will occur. This paper examines if absence of KIF1B is one of the key factor that leads to production of aneuploidy oocytes.
Perspectives
I hope this paper makes people know more about the mechanism of how the unhealthy oocytes could be produced. And in clinical application, we hope these new findings will help people pick out the unhealthy oocytes before it was used for in vitro fertilization.
Dr Cheng-Guang Liang
Inner Mongolia University
Read the Original
This page is a summary of: Loss of function of KIF1B impairs oocyte meiotic maturation and early embryonic development in mice, Molecular Reproduction and Development, October 2016, Wiley,
DOI: 10.1002/mrd.22744.
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