What is it about?
Nitroxides will interact with compounds. This interaction is difficult to follow by 1H NMR due to contact chemical shift broadening. However, 13C NMR allows us to look at the interaction using the one-bond J-ch.
Featured Image
Why is it important?
Nitroxide radicals act like paramagnetic compounds. The radical electron generates a magnetic field with a diameter of about 0.8 nm. Due to this radical, 1H NMR of nitroxide compounds yields broad spectra, with hydrogens near the NO radical almost invisible. 1H NMR shows shifting of compounds in contact with NO radicals. 13C allows us to follow the interaction better using a coupled 13C spectrum. Ultimately, we would like to observe the mechanism of oxidation by NO radicals.
Perspectives
Ultimately, we would like to observe the mechanism of oxidation by NO radicals. NO is used biologically in cell signalling. How does it work?
Martha Morton
University of Nebraska System
Read the Original
This page is a summary of: A 13
C NMR method for determining secondary nitroxide-substrate associations, Magnetic Resonance in Chemistry, August 2017, Wiley,
DOI: 10.1002/mrc.4637.
You can read the full text:
Contributors
The following have contributed to this page
