What is it about?
Unsymmetrical indirect covariance NMR methods can be used to mathematically calculate the equivalent of low sensitivity, hyphenated NMR experiments by combining data from a pair of higher sensitivity experiments.
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Why is it important?
Combining HSQC and NOESY spectra provides results comparable to HSQC-NOESY data but with greater sensitivity and with considerably less spectrometer time.
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This page is a summary of: The use of unsymmetrical indirect covariance NMR methods to obtain the equivalent of HSQC‐NOESY data, Magnetic Resonance in Chemistry, April 2007, Wiley,
DOI: 10.1002/mrc.1998.
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