A new strategy to attack the minimum MU problem in proton beam spot scanning

What is it about?

Intensity modulated proton therapy (IMPT), the most advanced form of spot scanning therapy is plagued by the fact that the treatment machine has a lower bound on the number of protons for which it can safely deliver a single spot. This is known as the minimum MU problem. If not dealt with properly in the treatment planning process this constraint may lead to sub-optimal dose distributions. In this paper we explore new treatment planning strategies which may minimize the negative impact of the minimum MU problem.

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Why is it important?

If not dealt with properly the minimum MU problem may lead to sub-optimal dose distributions, which in turn may lead to sub-optimal outcomes for patients treated with IMPT.