Robust intensity-modulated proton therapy to reduce high linear energy transfer in organs at risk

What is it about?

High LET radiation is known to harm healthy more than low LET radiation for the same physical dose. In this paper we show how to reduce LET in organs at risk while maintaining robust dose coverage in the target volume.

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Why is it important?

The treatment planning strategies discussed here may widen the therapeutic window for pencil beam scanning proton beam therapy by reducing the potential for damage to critical organs at risk.