What is it about?
We found that BrafV637E mutation is frequent mutation in the DEN-induced liver tumors in B6C3F1 mice.
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Why is it important?
BrafV637E mutation, which is found in several human cancers, plays an important role in DEN-induced liver tumors in B6C3F1 mice.
Perspectives
DEN is a widely used liver carcinogen in mouse tumor models. However, the mutational mechanism was not elucidated. By next generation sequencing, we found frequent mutation of BrafV637E mutation in liver tumors in B6C3F1 mice.
Masahiro Yamamoto
Asahikawa Medical University
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This page is a summary of: Role of theBrafV637E mutation in hepatocarcinogenesis induced by treatment with diethylnitrosamine in neonatal B6C3F1 mice, Molecular Carcinogenesis, June 2016, Wiley,
DOI: 10.1002/mc.22510.
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