What is it about?
Recently commercially available silica monolithic columns for HPLC offer much promise for undertaking chromatographic separations with higher flow rates and/or reduced system backpressure. Here we assessed how different size and shape aromatic molecules interacted with the base silica and silica modified with aminopropyl functionality under normal phase conditions.
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Why is it important?
Understanding how the structure of molecules controls their interaction with different stationary phases during separation helps scientists to develop methodologies for the separation of mixture components.
Perspectives
This work was part of my early career research where we tried to build on the recent innovation of monolithic columns to see if it would assist in the wider ambition of developing methods for unravelling crude oil complex mixtures. It also allowed me to travel to Moscow to visit with co-authors.
Dr Paul A Sutton
University of Plymouth
Read the Original
This page is a summary of: Retention characteristics of aromatic hydrocarbons on silica and aminopropyl‐modified monolithic columns in normal‐phase HPLC, Journal of Separation Science, November 2007, Wiley,
DOI: 10.1002/jssc.200700352.
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