The effect of disulfide bonds on protein folding, unfolding, and misfolding investigated by FT-Raman spectroscopy

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We provide a direct and spectroscopic evidence on how disulfide bonds work in the process of protein folding, unfolding, and misfolding. In this report, we prove that protein misfolding is closely related to the irreversible change of S-H / S-S conversion and protein secondary structure.

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