Organically Modified Silica Nanoparticles Interaction with Macrophage Cells: Assessment of Cell Viability on the Basis of Physicochemical Properties

Dhiraj Kumar, Isha Mutreja, Prashant C. Keshvan, Madhusudan Bhat, Amit K. Dinda, Susmita Mitra
  • Journal of Pharmaceutical Sciences, November 2015, Elsevier
  • DOI: 10.1002/jps.24614

organically modified silica nanoparticles as nano-carrier

What is it about?

The publication focuses on the synthesis of silica nanoparticles by the micro-emulsion method using OTES, VTES and APTES for hydroxyl and or amine terminal groups. We also studied the effect of size, concentration and surface chemistry on cellular uptake and cell viability of macrophages cells.

Why is it important?

The nanoparticle formulation can be employed for delivery of poorly soluble molecules.

Perspectives

Dr Dhiraj Kumar
University of Minnesota, Twin Cities

synthesis and application of organically modified silica nanoparticles synthesized by the micro-emulsion method as a carrier for poorly soluble drugs.

Read Publication

http://dx.doi.org/10.1002/jps.24614

The following have contributed to this page: Dr Dhiraj Kumar and Dr Isha Mutreja