Pain Receptors in Tendinopathy

What is it about?

Tendinopathy, chronic tendon pain, commonly known as tendinitis, tendonitis my be related to increased levels of pain receptors. We demonstrated that the pain glutamate receptor, N-methyl-D-aspartate receptor type 1 (NMDAR1), is 1.) up-regulated and 2.) activated (phosphorylated; phospho-NMDAR1) in tendinopathy. We moreover found that the activation, phosphorylation of NMDAR1, was due to increased levels of a signaling neuronal substance P and metabotropic co-receptors to NMDAR1.

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Why is it important?

The study demonstrated specific pathways and receptors, which may be used to develop targeted drugs for the treatment of tendinopathy.