What is it about?
In the present study, we hypothesized that the main reason of CD8+ T cells play "cytotoxic" role in the pathological process of SCI is the imbalance of CD8+CD28+/CD8+CD28− T cells in the injured area. This might be an important target for immune therapy of SCI. Therefore, in this study, we detected the dynamic change of these two cell subsets by combination of immunohistochemistry (IHC) and flow cytometry (FCM) to understand their temporal changes and to determine the "time window" for immune intervention.
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Why is it important?
Our results indicate that CD8+ T cells could rapidly infiltrate into the injured spinal cords and survive 2 weeks, however, cytotoxic CD8+ T cells were dominant. Therefore, two weeks after injury might be the “time window” for treating SCI by prolonging survival time and increasing the fraction of CD8+ regulatory T-cells.
Perspectives
I hope this article is helpful for immunotherapy of spinal cord injury. Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations.
He-Zuo Lü
Bengbu Medical College
Read the Original
This page is a summary of: Temporal kinetics of CD8+
CD28+
and CD8+
CD28−
T lymphocytes in the injured rat spinal cord, Journal of Neuroscience Research, November 2016, Wiley,
DOI: 10.1002/jnr.23993.
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