What is it about?
In the present study, we hypothesized that the main reason of CD8+ T cells play "cytotoxic" role in the pathological process of SCI is the imbalance of CD8+CD28+/CD8+CD28− T cells in the injured area. This might be an important target for immune therapy of SCI. Therefore, in this study, we detected the dynamic change of these two cell subsets by combination of immunohistochemistry (IHC) and flow cytometry (FCM) to understand their temporal changes and to determine the "time window" for immune intervention.
Photo by vaun0815 on Unsplash
Why is it important?
Our results indicate that CD8+ T cells could rapidly infiltrate into the injured spinal cords and survive 2 weeks, however, cytotoxic CD8+ T cells were dominant. Therefore, two weeks after injury might be the “time window” for treating SCI by prolonging survival time and increasing the fraction of CD8+ regulatory T-cells.
Read the Original
This page is a summary of: Temporal kinetics of CD8+
T lymphocytes in the injured rat spinal cord, Journal of Neuroscience Research, November 2016, Wiley, DOI: 10.1002/jnr.23993.
You can read the full text:
The following have contributed to this page