What is it about?
The suprachiasmatic nucleus (SCN) functions as the major circadian oscillator in the body. It is sensitive to various external cues that affect its setting and, thus, the timing of many physiological processes. Using immunohistochemistry, we demonstrate the presence of signal transducers and activators of transcription (STAT) 3, STAT5A, and STAT5B in the rat SCN. Although the role of both STAT5 forms in the SCN remains elusive, STAT3 is activated by bacterial endotoxin in a time-dependent manner and may be involved in the immune responses of the SCN astrocytes.
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Why is it important?
Our data show for the first time the daily rhythm of STAT3 in the SCN and suggests its involvement in homeostatic processes in the SCN astrocytes in response to inflammation.
Perspectives
We hope that this pioneering research will inspire further studies on the STAT3 a STAT5 role in the SCN.
Zdenka Bendová
Faculty of Science, Charles University
Read the Original
This page is a summary of: Identification of STAT3 and STAT5 proteins in the rat suprachiasmatic nucleus and the Day/Night difference in astrocytic STAT3 phosphorylation in response to lipopolysaccharide, Journal of Neuroscience Research, September 2015, Wiley,
DOI: 10.1002/jnr.23673.
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