What is it about?
Human respiratory syncytial virus (HRSV) is a major pathogen that causes worldwide seasonal epidemic disease in infants due to its genetic variations. The local HRSV epidemic was associated with the alternate circulation of multiple genotypes and with the change of glycosylation sites of G protein.
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Why is it important?
Five HRSV genotypes NA1, ON1, BA9, BA-C and CB1 were found in Chengdu. The predominant circulating genotype changed from NA1 in the period of 2010-2012 to BA9 of 2013-2014. The newly emerging ON1 was first reported in West China in October 2013. The early genotypes BA-C and CB1 were replaced by the prevailing BA9 after the third epidemic peak. The study provides essential baseline data, and associates the significance of age, gender, seasonality, circulation and variation of HRSV genotypes with the disease prevalence and characteristics.
Perspectives
It is necessary for public health researchers to conduct long-term HRSV molecular epidemiological surveys. The results from this study will help the authorities to understand the epidemic patterns, predict the potential outbreaks, and form the control, prevention and treatment strategies.
Xiaofang Pei
Sichuan University
Read the Original
This page is a summary of: Alternate circulation and genetic variation of human respiratory syncytial virus genotypes in Chengdu, West China, 2009-2014, Journal of Medical Virology, June 2016, Wiley,
DOI: 10.1002/jmv.24603.
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