What is it about?
IL-17 rs2275913 (GG and AG) were associated with risk of infection with that were statistically significant (P<0.05, OR¼2.08–2.94). IL-1b (rs16944) (GG) was associated with reduced risk of infection (P<0.01, OR¼0.46). Genotype GG and GT of IL-10 (rs1800872) were associated with increased risk of infection with influenza A/H3N2 virus (P<0.05, OR¼2.04–2.58). In addition, IL-28 (rs8099917) genotypes GG (P<0.05, OR¼0.49) and TG (P<0.05, OR¼0.59) were associated with reduced risk of ILI symptom while genotype TT (P<0.01, OR¼4.31) was associated with increased risk of ILI symptom.
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Why is it important?
The results of this study demonstrated that polymorphisms of genes involved in the inflammatory and anti-inflammatory process affect the outcome of disease caused by influenza A/H3N2 virus.
Perspectives
Thorough insight on host immune response at the time of influenza A virus infection is required to ensure adequate patient care in the case of feature outbreaks.
LAWAL DAHIRU ROGO
BAYERO UNIVERSITY KANO
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This page is a summary of: Seasonal influenza A/H3N2 virus infection and IL-1Β, IL-10, IL-17, and IL-28 polymorphisms in Iranian population, Journal of Medical Virology, July 2016, Wiley,
DOI: 10.1002/jmv.24572.
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