What is it about?
Negative ion mode MALDI of neutral oligosaccharides has unique properties for their structural analysis. Many strategies have been proposed in order to exploit a common feature of their instability in the negative ion mode, yielding cross-ring product ions, which are of great importance in structural analysis of oligosaccharides. Here a simple method without anionic dopant strategies has been described.
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Why is it important?
Production of cross-ring fragment ions is of primary importance for detailed MS/MS structural analysis of oligosaccharides. Also, MALDI source chemistry is a complex topic, poorly studied, yet needs to be understood in order to advance MALDI MS. MALDI has been previously used for performing reactions on the target, prior MS analysis. In-source chemical reactivity is more complex, and its uses and limitations need to be further studied.
Perspectives
MALDI has been previously used for performing reactions on the target, prior to MS analysis. In-source chemical reactivity is more complex, and its uses and limitations need to be further studied.
Dr Marko Haramija
University of Rijeka
Read the Original
This page is a summary of: Negative ion MALDI-TOF MS, ISD and PSD of neutral underivatized oligosaccharides without anionic dopant strategies, using 2,5-DHAP as a matrix, Journal of Mass Spectrometry, February 2016, Wiley,
DOI: 10.1002/jms.3727.
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