Hyaluronidase modulates bleomycin-induced lung injury as monitored by MRI

What is it about?

To assess whether hyaluronic acid, a building block of proteoglycans and extracellular matrix with hydrophilic characteristics, might contribute to magnetic resonance imaging (MRI)-detected proton signals elicited by bleomycin in the lung. To this end, hyaluronidase, which degrades hyaluronic acid, was administered to bleomycin-challenged animals.

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Why is it important?

The present data indicate that hyaluronic acid contributes to the bleomycin-induced responses detected by MRI in the lung.

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