What is it about?
L-Histidine is an important amino acid present in biological proteins and used to synthesise variety of bioactive peptides. Modification of L-histidine required to developed proteolytically stable peptides. Here, we developed highly efficient strategy for regiospecific alkylation of L-histidine.
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Why is it important?
The given scheme is very important to produce structurally diverse amino acids for development of novel and stable bioactive peptides.
Perspectives
This article came out after more than 6 month extensive synthetic work and it would lead to discovery of various novel peptide scaffolds of biological importance.
Dr Surendra Kumar Nayak
Adesh University Bathinda
Read the Original
This page is a summary of: Facile regiospecific syntheses of N-α,N-1(τ)-dialkyl-l-histidines, Journal of Heterocyclic Chemistry, November 2007, Wiley,
DOI: 10.1002/jhet.5570440607.
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