What is it about?
The sulfenylation of aryl compounds is an important issue in synthetic organic chemistry. Various methods are available for the sulfenylation of the organic compounds. The reaction with sulfenyltosylates proceeds best with phenolic substrates under basic conditions. Some of the sulfenylated compounds are effective against HIV, fungicidal and antiseptic activities.
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Why is it important?
In the present paper it is reported, that dialkylaminothiocarbonylthio derivatives are obtained by two alternative routes. The starting 1,3-dicarbonyl compounds of the type 1, 4, and 6 are converted to their 3-chloro derivatives or their 3-phenyliodonium. The commercially available thiuram disulfides are used for the sulfinylation of 1,3-dicarbonyl systems. The present method has high value in organic synthesis because of operational simplicity, as well as good availability of the starting materials.
Perspectives
We have developed a simple, convenient one-pot synthesis method to prepare dithio-carbamide derivatives of heterocyclic 1,3-dicarbonyl systems, such as 4-hydroxy-2,5-pyranopyridines, 4-hydroxy-2-pyridones, 4-hydroxy-2-quinolones, 4-hydroxy coumarins, and 4-hydroxy-1-methyl-2-quinolones. The present method may be of value in organic synthesis because of operational simplicity, as well as good availability of the starting materials.
Dr B. P. NIKAM
RIT, SAKHARALE
Read the Original
This page is a summary of: A Simple, Convenient One‐Pot Synthesis of Dithio‐Carbamide Derivatives of Heterocyclic 1,3‐Dicarbonyl Systems, Journal of Heterocyclic Chemistry, August 2016, Wiley,
DOI: 10.1002/jhet.2754.
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