Novel spiro-oxindole-isoxazolidine derivatives as potent antioxidant agents

What is it about?

Several endeavours have been committed to the synthesis of aldonitrones, mainly because of simple condensation reaction of N-alkylhydroxylamine or N-arylhydroxylamine with corresponding aldehydes. In contrast, the preparation of ketonitrones may not always be accomplished by simple condensation reactions and occasional reports of synthetic routes toward these compounds have been reported. Due to the above reasons, in continuation of our ongoing investigations, the 1,3-dipolar cycloaddition reactions of N-substituted maleimides with isatin ketonitrone under refluxing in acetonitrile resulted in the formation of a series of new spiro[oxindoleisoxazolidine] derivatives in highly regioselective and diastereoselective manner which were characterized through their melting point, elemental analyses, IR, 1H-NMR, 13C-NMR, 1H, 1H-COSY, and mass spectral studies.

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Why is it important?

The above results help us to promote the synthesis of novel spiro (oxindole isoxazolidine) derivatives synthesized from isatin ketonitrone are found to be interesting lead molecules as antioxidant agents.