What is it about?
Methionine (Met) is an essential amino acid for cancer cells. We have shown that Met modification can endow drug carriers targeting action. The siRNA carriers can reverse the drug resistance of breast cancer cell line.
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Why is it important?
Our study shows that methionine is an alternative cancer target group. 1. Guanidine and methionine grafted DHPMA-b-APMA block copolymer (mDG) has much more hydroxy groups which can bring water-soluble, good biocompatibility and limiting precipitation of mDG/siRNA complex. 2. Driven by the amine functionality in APMA segments, mDG copolymer could conjugate targeting moieties (methionine) and cell penetrating moieties (guanidine). 3. mDG/siRNA complex has small size less than 150 nm which could actively and passively target solid tumors via methionine -mediate cell uptake and the enhanced permeability and retention effect. 4. mDG/siRNA complex could generate synergistic anticancer effects and efficiently re-sensitize DOX-resistant breast cancer cells (MCF-7/ADR) to the anticancer drug DOX through the selective inhibition of P-gp.
Perspectives
I hope this article can provide illumination and insight for researchers who have been trying to develop anti-cancer drugs and methods.
Jin-Hai Tang
Nanjing Medical University
Read the Original
This page is a summary of: Multivalent methionine-functionalized biocompatible block copolymers for targeted small interfering RNA delivery and subsequent reversal effect on adriamycin resistance in human breast cancer cell line MCF-7/ADR, The Journal of Gene Medicine, August 2017, Wiley,
DOI: 10.1002/jgm.2969.
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