Antipyretic effect of clonidine

What is it about?

Fever in ICU is usually an adaptive response to infection or inflammation. Pharmacological intervention is often required in addition to addressing the underlying causes of fever.Our report is the first of its kind in humans which demonstrates possible antipyretic properties of enteral clonidine in the critically ill intensive care unit patients.

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Why is it important?

Significant progress has been made in the development of mechanical devices, both extracorporeal and intravascular, for cooling critically ill, febrile patients, but the number of antipyretic drugs for this patient population remains limited. This study is the first of its kind to examine the effect of clonidine on fever in critically ill ICU patients. Our observations could suggest that clonidine has antipyretic effects – possibly a new indication for this agent in hemodynamically stable ICU patients.