What is it about?
This paper identifies a mathematical model that can accurately describe both how the etroliozumab drug concentration in the serum changes over time and how the pharmacological effect of the drug behave over time. This helps physicians and researchers to understand how to best treat patients with ulcerative colitis or other inflammatory bowel diseases using this biologic drug which is under the development.
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Why is it important?
This mathematic model allows to accurately predict the pharmacological effect and drug concentration profiles of Etrolizumab when given at different dose levels and dose frequencies. This helps the researchers to best design the pivotal studies and facilitate the identification of the best option for how to treat the patients with inflammatory bowel diseases.
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Read the Original
This page is a summary of: Pharmacokinetic and Pharmacodynamic Modeling of Serum Etrolizumab and Circulating β7 Receptor Occupancy in Patients With Ulcerative Colitis, The Journal of Clinical Pharmacology, November 2017, Wiley,
DOI: 10.1002/jcph.1031.
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