What is it about?
In this review, we focused on the role of ILCs in inflammation, allergy, and autoimmune disorders.
Featured Image
Why is it important?
ILCs affect the initial stages of immunity in response to microbes and participate in immunity, inflammation, and tissue repair. ILCs modulate immunity through resistance to the pathogens and regulation of autoimmune inflammation and metabolic homeostasis. Therefore dysregulation of ILCs may lead to chronic pathologies such as allergies (i.e., asthma), inflammation (i.e., inflammatory bowel disease), and autoimmunity (i.e., psoriasis, atopic dermatitis, rheumatoid arthritis, multiple sclerosis, and ankylosing spondylitis).
Perspectives
Regarding the critical role of ILCs in the regulation of immune system, the elucidation of their function in different conditions makes an interesting target for improvement of novel therapeutic approach to modulate an immune response in a different disease context.
Hamed Mohammadi
Read the Original
This page is a summary of: The role of innate lymphoid cells in health and disease, Journal of Cellular Physiology, January 2018, Wiley,
DOI: 10.1002/jcp.26250.
You can read the full text:
Contributors
The following have contributed to this page
