What is it about?
Our study determined that NOD1 activation inhibits SERT activity and expression in Caco-2/TC7 cells, with ERK/MAPK being the intracellular pathway involved. Moreover, the increment of extracellular 5-HT bioavailability, due to NOD1 activation, could also modify the receptor by itself in a negative feedback. In this context, our work has also pointed out that the activation/depletion of other PRRs (TLR2 and TLR4) could affect NOD1 and in turn, NOD1 activation could influence TLR2 and TLR4, which could also modify SERT.
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Why is it important?
These results deepen the knowledge of the serotonergic response in homeostasis but also in intestinal inflammation, as well as the interaction of different PRRs in the host defense against pathogenic agents in the intestine.
Perspectives
It contributes to our knowledge of the regulation of both the intestinal serotonergic system and innate immune system, under physiological and pathological conditions.
Jose Emilio Mesonero
Universidad de Zaragoza
Read the Original
This page is a summary of: NOD1 downregulates intestinal serotonin transporter and interacts with other pattern recognition receptors, Journal of Cellular Physiology, December 2017, Wiley,
DOI: 10.1002/jcp.26229.
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