What is it about?
Spleen Tyrosine Kinase enzymes is a member of the Syk family of tyrosine kinases. Here, we explored the roles of Syk in BMSC differentiation into adipocytes and osteoblasts. Our finding indicate that Syk-PLCγ signaling has a dual role in regulating the initial stage of adipogenic and osteogenic differentiation of BMSCs.
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Why is it important?
Our findings added important understanding of BMSCs differentiation. Especially in the initial stage and also the role of Syk enzymes.
Perspectives
Inadequate BMSC differentiation is occasionally implicated in chronic bone metabolic disorders. Further elaboration in BMSCs differentiation, especially into osteoblastic lineage will add basic understanding about bone regeneration.
Muhammad Subhan Amir
Kagoshima Daigaku
Read the Original
This page is a summary of: Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities, Journal of Cellular Physiology, September 2017, Wiley,
DOI: 10.1002/jcp.26130.
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