What is it about?
This journal paper studied the function of the (2) N-glycan sites of the Kv3.1b protein which is concluded to vary due to sugar structure differences.
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Why is it important?
The study highlighted the action of N-glycans to the brain voltage-gated potassium channel Kv3.1b protein on its trafficking and expression on the cell surface for the protein to perform its duty. This is similar to mutated cancer proteins having much glycosylation moieties on their cell surface which are used for cellular attachment.
Perspectives
N-glycan "sugar" structures on proteins may differ in structure and function and can be studied with mammalian cell lines that have cellular machinery almost similar to a native tissue.
Mr Paul Christian Vicente
Kyung Hee University
Read the Original
This page is a summary of: Identification and characterization of site-specific N-glycosylation in the potassium channel Kv3.1b, Journal of Cellular Physiology, May 2017, Wiley,
DOI: 10.1002/jcp.25915.
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