What is it about?
Retinal pigmented epithelial cells are degenerated in retinal diseases . We have studies gene delivery effect on cell survival and have shown over-expression of one master regulator can promote cell adaptation to stress.
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Why is it important?
This is the first report on virus mediated delivery of Grp78 gene to primary human retinal pigmented epithelial cells which introduces GRP78 as a key survival factor and useful candidate for future investigations of retinal degeneration.
Perspectives
I am proud of my scientific team who helped me to do such a cutting-edge research in a developing country like Iran with limited facilitation and finance resources. I hope readers find this article novel and well-designed.
Shima Ghaderi
University of Tehran
Read the Original
This page is a summary of: AAV delivery of GRP78/BiP promotes adaptation of human RPE cell to ER stress, Journal of Cellular Biochemistry, September 2017, Wiley,
DOI: 10.1002/jcb.26296.
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