What is it about?
The diagnosis of acute kidney injury (AKI) is frequently established on modifications in serum creatinine (SCr). The discriminative and prognostic aptitudes of serum cystatin-C as well as Nacetylglucosaminidase (NAG) and Interleukin-18 (IL-18) were inspected for the estimation of AKI. In this study twelve rats were alienated into two groups: control group received saline, second group received cadmium chloride at a dose (2.4 mg Cd/kg/day, i.p) for 30 days. Blood urea nitrogen (BUN), SCr, and IL-18 serum level were measured in addition to serum and tissue content of cystatin-C and NAG. AKI model showed significant increase in BUN, creatinine, and IL-18. RT-PCR showed upregulation of cystatin-C gene besides significant increase of its level in serum.Additionally, tissue content of NAG was significantly increased.
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Why is it important?
Cystatin-C is a promising biomarker and more precise than creatinine. Combination of cystatin-C and IL-18 serum level is a more valuable indicative tool than single-marker assessment. There was significant correlation between pro-inflammatory IL-18 and cystatin-C,NAG, and creatinine.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have had long standing collaborations. the important way to manage any disease is early diagnosis, so this publication show the best way for early diagnosis
hend hassan
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This page is a summary of: Relevance of cystatin-C, N-acetylglucosaminidase, and Interleukin-18 with the diagnosis of acute kidney injury induced by cadmium in rats, Journal of Biochemical and Molecular Toxicology, July 2017, Wiley,
DOI: 10.1002/jbt.21968.
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