What is it about?
To translate basic research findings to practical applications validation and evaluation of cell and tissue toxicity are required for any kind of molecule, including peptides. This article refers to the toxicity evaluation in zebrafis model of a promising peptide that display anti-infective and antiproliferative activities.
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Why is it important?
Selectivity and specificity are properties of natural and engineered peptides useful for target therapies and diagnostic.
Perspectives
Peptides are amenable to protein engineering and researchers can customize their sequences by looking at the relation activity versus toxicity, that is, structure-activity-toxicity can be adjusted according to experimental data and peptide tailoring.
Gandhi Rádis-Baptista
Universidade Federal do Ceara
Read the Original
This page is a summary of: Evaluation in zebrafish model of the toxicity of rhodamine B-conjugated crotamine, a peptide potentially useful for diagnostics and therapeutics, Journal of Biochemical and Molecular Toxicology, August 2017, Wiley,
DOI: 10.1002/jbt.21964.
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