Effective healing of chronic rotator cuff injury using recombinant bone morphogenetic protein-2 coated dermal patch in vivo

Kwang-Won Lee, Jung-Soo Lee, Young-Sik Kim, Young-Bock Shim, Ju-Woong Jang, Kwang-Il Lee
  • Journal of Biomedical Materials Research Part B Applied Biomaterials, May 2016, Wiley
  • DOI: 10.1002/jbm.b.33716

Translational research_Rotator cuff repair

What is it about?

Biologic augmentation for rotator cuff repair is a challenging treatment in patients with chronic large, massive, and irreparable rotator cuff injuries. Particularly, the use of an extracellular matrix (ECM) patch such as dermal tissue offered improved biomechanical properties in previous studies. Cytokines induce cell chemotaxis, proliferation, matrix synthesis, and cell differentiation.Moreover, osteoinductive growth factors such as bone morphogenetic protein-2 (BMP-2) affect the formation of new bone and fibrocartilage in lesions. However, the effects of using a dermal patch in combination with BMP-2 have not been evaluated to date, although many researchers have recognized the importance thereof. In this study, rhBMP-2-coated dermal patch (1 cm 3 2 cm) isolated from human cadaveric donor was inserted in a rabbit model of chronic rotator cuff injury for in vivo evaluation. Bone mineral density and biomechanical strength were tested and histological and histomorphometric analyses were performed.

Why is it important?

The results showed that insertion of an rhBMP- 2-coated acellular dermal patch not only significantly ameliorated new bone formation, it also improved biomechanical properties such as ultimate tensile strength. Thus, the use of this combination may improve the chronic rotator cuff injury-healing rate and clinical outcomes after rotator cuff repair.

Perspectives

Dr. Kwang il Lee
The Scripps Research Institute

The grafting of rhBMP-2-coated human dermal patch induced new bone formation and increased the bone–tendon fusion rate in a rabbit chronic rotator cuff injury model. This study demonstrated that the combination of dermal patch and rhBMP-2 can be applied to the rotator cuff injured patients.

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http://dx.doi.org/10.1002/jbm.b.33716

The following have contributed to this page: Dr. Kwang il Lee