What is it about?
Particle-induced osteolysis is a major issue, and it is most likely the result of enhanced osteoclast activation in the pathogenesis of various skeletal diseases.
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Why is it important?
Our results suggest that the natural compound Polycan is a good candidate for therapeutic intervention against enhanced osteoclast differentiation and Ti particleinduced osteolysis.
Perspectives
Polycan suppressed Ti particleinduced osteolysis by inhibiting osteoclast differentiation and activation in vitro and in vivo. Therefore, our findings indicate that Polycan can be applied as a biomaterial to reduce Ti particle-induced osteolysis.
Professor YOUNG EUN LEE
Daegu Health College
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This page is a summary of: Polycan suppresses osteoclast differentiation and titanium particle-induced osteolysis in mice, Journal of Biomedical Materials Research Part B Applied Biomaterials, June 2015, Wiley,
DOI: 10.1002/jbm.b.33415.
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