What is it about?
Prediction of outcome for patients with head and neck cancer at diagnosis is difficult. In a multicenter DKTK study Hsp70 expression and tumor-infiltrating NK cells in tumor sections of head and neck cancer patients at diagnosis have been found to be indicative for clinical outcome. High Hsp70 levels and low numbers of infiltrating NK cells within the tumor tissue are predictive for a negative clinical outcome.
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Why is it important?
Tumor biomarkers that are indicative for clinical responses before start of therapy are important for a personalized anti-cancer therapy and for therapy adaptations.
Perspectives
This article summarizes the results of a multicenter retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG). The results will help to improve clinical outcome of patients with head and neck cancer by a more individualized therapy adaptation.
Gabriele Multhoff
TUM
Read the Original
This page is a summary of: Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Gro, International Journal of Cancer, December 2017, Wiley,
DOI: 10.1002/ijc.31213.
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